J Neurol Sci. Jan 21;(1) Clinical diagnosis in Karwinskia humboldtiana polyneuropathy. Martínez HR(1), Bermudez MV, Rangel-Guerra RA. Toxicon. May;53(6) doi: /n Karwinskia humboldtiana (buckthorn) fruit causes central nervous system damage during. Karwinskia humboldtiana. Karwinskia humboldtiana (Schult.) Zucc. Coyotillo, Humboldt Coyotillo. Rhamnaceae (Buckthorn Family). Synonym(s).

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Intoxication with buckthorn (Karwinskia humboldtiana): report of three siblings.

The plant was apparently more useful as a medicine. Despite its toxic properties, parts of the coyotillo plant was used for medicinal purposes and, perhaps, even as starvation food by one group. Despite its deservedly poisonous reputation, coyotillo seeds, branches, and leaves were recovered from Early Archaic, Middle Archaic, and Late Archaic contexts at Hinds Cave Dering Tragically, marwinskia are its most common victims. The availability of toxin detection in blood samples allows the clinician to hhmboldtiana an accurate diagnosis and should be included in the study of children with polyradiculoneuropathy, especially in countries where this poisonous plant grows.

Coyotillo shrub near the Pecos River. Coyotillo, Tullidora Karwinskia humboldtiana Schult.

In two of these cases, a sural nerve biopsy revealed a segmental demyelination with swelling and phagocytic chambers in Schwann cells and without lymphocytic infiltration. Although many victims karwinakia completely, in serious cases they are left quadriplegic. Clinical diagnosis in poisoned humans may be difficult if no evidence of previous fruit ingestion is available.

Coyotillo is a very poisonous plant, and stockmen know to introduce only livestock that are familiar with the vegetation of the region, or to feed plenty of supplements to those animals that aren’t. This Rhamnaceae article is a stub. My concern is that the relaxation might well be permanent.


This is the first report about the presence of neuronal damage caused by Kh in the Central Nervous System in chronic intoxication.

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We designed an open trial at the Pediatric Neurology service and included all cases with acute ascending paralysis that were admitted to our hospital in the last two years.

Goats, sheep, and cattle humbokdtiana all susceptible Lyons and Machen Electrodiagnostic studies were performed, including motor conduction velocities, distal latencies, F-wave latency and compound muscle action potential CAMP amplitude. The fruit is the most humboldtkana part of the Coyotillo plant, or, at least the seed inside the fruit.

But an experiment conducted on livestock clearly illustrates how the dangers of coyotillo fruit. In six cases, T Karwinskia humboldtiana toxin was detected. In a classic work on Mexican medicinal plants, Maximino Martinez humgoldtiana more space to describing the poisonous effects of coyotillo than he does to its healing applications.

karwinskia humboldtiana

Small wonder so many children in Mexico are poisoned by this common and deadly shrub. These occurances beg the question: Coyotillo is commonly found across northern Mexico in limestone soils, including the states of Nuevo Leon, Coahuila, Chihuahua, and Sonora, but it grows throughout much of Mexico.

In all cases, we performed hematological, immunological and biochemical profiles, CSF analysis including immunological studies, oligoclonal bands and myelin basic protein determinations.

You can help Wikipedia by expanding it. Its common name in Mexico, tullidora, is rendered from the verb “tullir,” to cripple. Ingestion of the fruit causes damage to nerves as well as the pulmonary system and the liver.

We considered it important to evaluate, with histological techniques, the possible presence of lesions in the brain, by using a model of chronic intoxication that reproduces the same stages present in the human intoxication, to better understanding of this pathological process. In this polyneuropathy the lesion demyelization in peripheral nerves has been described in several animal species, both in acute and in chronic intoxication. New York, New York: Only one patient required assisted ventilation due to bulbar paralysis.


In conclusion, although the native poeples of the Lower Pecos Canyonlands apparently did use Coyotillo in some way, it is a highly dangerous plant. Coyotillo is a small, evergreen shrub with deep green, almost glossy and distinctively veined leaves that grow opposite each other along the stem. University of Texas Press.

Their Environment and Material Culture. The poisoning manifests itself as ascending paralysis, starting in the extremities and moving toward the trunk, and in extreme cases victims need mechanical assistance to breathe. Although the fruit is much more poisonous than the leaves, there is some discussion that the flesh of the fruit is either non poisonous or less poisonous, and that the single seed inside the pulpy fruit contains the bulk of the neurotoxins.

As an external headache remedy, the leaves were wrapped in a cloth which was in turn tied around the head. Articles with ‘species’ microformats Commons category link from Wikidata Commons category link is on Wikidata All stub articles. Wikimedia Commons has media related to Karwinskia humboldtiana.